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MLB Predictions for September 23, 2026: Every Game Previewed

2026-09-23 · Posted at 9:41 AM ET

Preview for Wednesday, September 23, 2026. Schedule and player information can change.

Washington Nationals at Detroit Tigers

The Nationals head to Detroit with a lineup carrying a 0.322 wOBA against a Tigers offense at 0.313, but Detroit's pitching staff has the clear edge with a 4.09 FIP and 3.64 ERA compared to Washington's 4.77 FIP and 4.67 ERA. That gap in run prevention looks like the deciding factor even though the Nationals have hit a bit better as a team this season.

On the mound, Richard Lovelady carries a 3.86 ERA but a 5.13 FIP over approximately 32.7 innings, suggesting his results have outrun his peripherals. Framber Valdez brings a heavier workload at approximately 168.7 innings with a 4.06 ERA and 4.26 FIP, figures that are closer together and point to a more stable form. Tyler Baum and Connelly Early are both listed on the 60-Day IL for Washington, while Kerry Carpenter is listed on the 10-Day IL, Paul DeJong on the 60-Day IL and Kyle Finnegan on the 15-Day IL for Detroit.

Statistical scope: MLB Stats API; 2026 regular season season-to-date; exact statistical through-date not supplied.

WP selection: Nationals +1.5. Confidence: Slight Lean.

The selection is supplied separately by WP. The comparisons above do not establish why the model made this selection.

WP home-run candidate for Nationals: Yohandy Morales. The selection uses roster and season-stat inputs; it does not establish a confirmed batting lineup or favourable betting odds.

WP home-run candidate for Tigers: Eduardo Valencia. The selection uses roster and season-stat inputs; it does not establish a confirmed batting lineup or favourable betting odds.

Minnesota Twins at San Francisco Giants

Minnesota's offense checks in with a 0.312 wOBA against San Francisco's 0.308, a narrow gap, while the Giants hold a slight team pitching edge with a 4.32 FIP against the Twins' 4.31 FIP, though Minnesota's 4.58 ERA trails San Francisco's 4.36 ERA. Both clubs are working with middling run-prevention marks, making this one of the tighter statistical matchups on the slate.

Connor Prielipp has logged approximately 120.3 innings with a 4.94 ERA but a notably better 3.83 FIP, hinting his results have been worse than his underlying numbers. Cesar Perdomo has thrown just approximately 19.3 innings with a 3.72 ERA against a 5.03 FIP, the reverse pattern. Willy Adames is listed on the 10-Day IL and Harrison Bader on the 60-Day IL for San Francisco, while Mick Abel and Eduardo Beltre are listed on the 60-Day IL and Anthony Banda on the 15-Day IL for Minnesota.

Statistical scope: MLB Stats API; 2026 regular season season-to-date; exact statistical through-date not supplied.

WP selection: Giants +1.5. Confidence: Slight Lean.

The selection is supplied separately by WP. The comparisons above do not establish why the model made this selection.

WP home-run candidate for Giants: Victor Bericoto. The selection uses roster and season-stat inputs; it does not establish a confirmed batting lineup or favourable betting odds.

WP home-run candidate for Twins: Emmanuel Rodriguez. The selection uses roster and season-stat inputs; it does not establish a confirmed batting lineup or favourable betting odds.

St. Louis Cardinals at Pittsburgh Pirates

Pittsburgh's pitching staff holds a clear edge over St. Louis, posting a 3.89 FIP and 4.16 ERA compared to the Cardinals' 4.17 FIP and 4.28 ERA, while the Pirates' offense also carries a higher 0.321 wOBA against St. Louis's 0.304. Both figures point toward Pittsburgh as the stronger overall club in this matchup.

Matthew Liberatore has worked approximately 149.3 innings with a 5.36 ERA and 4.74 FIP, numbers that lag behind Lake Bachar's approximately 83.3 innings with a 3.56 ERA and 4.55 FIP. Braxton Ashcraft is listed on the 15-Day IL and Kyler Fedko on the 7-Day IL for Pittsburgh, while Joshua Baez is listed on the 10-Day IL and Hunter Dobbins on the 15-Day IL for St. Louis.

Statistical scope: MLB Stats API; 2026 regular season season-to-date; exact statistical through-date not supplied.

WP selection: Pirates moneyline. Confidence: Confident.

The selection is supplied separately by WP. The comparisons above do not establish why the model made this selection.

WP home-run candidate for Cardinals: Leo Bernal. The selection uses roster and season-stat inputs; it does not establish a confirmed batting lineup or favourable betting odds.

WP home-run candidate for Pirates: Rafael Flores Jr.. The selection uses roster and season-stat inputs; it does not establish a confirmed batting lineup or favourable betting odds.

Milwaukee Brewers at Philadelphia Phillies

Milwaukee brings the better offensive and pitching profile into Philadelphia, with a 0.324 wOBA topping the Phillies' 0.308, and a 3.79 FIP and 3.55 ERA that both undercut Philadelphia's 3.86 FIP and 4.00 ERA. The Brewers look sharper across the board on the season-to-date numbers.

Logan Henderson has been especially efficient over approximately 93.3 innings, posting a 2.51 ERA and 3.37 FIP, both stronger than Aaron Nola's approximately 168.3 innings with a 4.49 ERA and 4.86 FIP. Grant Anderson is listed on the 15-Day IL for Milwaukee, while Adolis Garcia and Connor Gillispie are both listed on the 60-Day IL for Philadelphia.

Statistical scope: MLB Stats API; 2026 regular season season-to-date; exact statistical through-date not supplied.

WP selection: Brewers moneyline. Confidence: Confident.

The selection is supplied separately by WP. The comparisons above do not establish why the model made this selection.

WP home-run candidate for Brewers: Gary Sánchez. The selection uses roster and season-stat inputs; it does not establish a confirmed batting lineup or favourable betting odds.

WP home-run candidate for Phillies: Bryce Harper. The selection uses roster and season-stat inputs; it does not establish a confirmed batting lineup or favourable betting odds.

Tampa Bay Rays at New York Yankees

This matchup has the Tampa Bay Rays visiting the New York Yankees. The listed start is 7:05 PM ET.

Ian Seymour, the listed starter for the Tampa Bay Rays, has an ERA of 4.38 and a WP-calculated FIP of 4.25 in the available pitching data, covering approximately 127.3 innings. Gerrit Cole, the listed starter for the New York Yankees, has an ERA of 3.63 and a WP-calculated FIP of 3.99 in the available pitching data, covering approximately 121.3 innings. These are schedule listings, not independent confirmation of the final starters.

Team statistics for the Tampa Bay Rays show a WP-estimated wOBA of 0.317, a WP-estimated FIP of 4.07 and an ERA of 3.67. Team statistics for the New York Yankees show a WP-estimated wOBA of 0.311, a WP-estimated FIP of 3.76 and an ERA of 3.21.

Statistical scope: MLB Stats API; 2026 regular season season-to-date; exact statistical through-date not supplied.

WP selection: Rays +1.5. Confidence: Slight Lean.

The selection is supplied separately by WP. The comparisons above do not establish why the model made this selection.

WP home-run candidate for Rays: Victor Mesa Jr.. The selection uses roster and season-stat inputs; it does not establish a confirmed batting lineup or favourable betting odds.

WP home-run candidate for Yankees: Luis García Jr.. The selection uses roster and season-stat inputs; it does not establish a confirmed batting lineup or favourable betting odds.

Cleveland Guardians at Boston Red Sox

Boston's staff has the edge over Cleveland with a 3.74 FIP and 3.59 ERA against the Guardians' 3.89 FIP and 3.77 ERA, while the Red Sox offense also checks in with a higher 0.314 wOBA compared to Cleveland's 0.304. Both marks favor Boston heading into this one.

Sonny Gray has been outstanding over approximately 163.0 innings, with a 2.82 ERA and 3.57 FIP, both better than Foster Griffin's approximately 166.7 innings with a 3.67 ERA and 4.14 FIP. Kristian Campbell is listed on the 7-Day IL and Triston Casas on the 60-Day IL for Boston, while Jonah Advincula is listed on the 7-Day IL and Shawn Armstrong on the 60-Day IL for Cleveland.

Statistical scope: MLB Stats API; 2026 regular season season-to-date; exact statistical through-date not supplied.

WP selection: Guardians +1.5. Confidence: Slight Lean.

The selection is supplied separately by WP. The comparisons above do not establish why the model made this selection.

WP home-run candidate for Guardians: Angel Martínez. The selection uses roster and season-stat inputs; it does not establish a confirmed batting lineup or favourable betting odds.

WP home-run candidate for Red Sox: Mickey Gasper. The selection uses roster and season-stat inputs; it does not establish a confirmed batting lineup or favourable betting odds.

Cincinnati Reds at Atlanta Braves

Atlanta's pitching staff has a clear advantage over Cincinnati, posting a 3.62 ERA against the Reds' 4.86 ERA, even though the FIP gap is closer at 4.17 for the Braves and 4.89 for the Reds. Atlanta's offense also carries a slightly higher 0.312 wOBA compared to Cincinnati's 0.305.

Chris Sale has been dominant across approximately 157.0 innings, posting a 2.18 ERA and 2.35 FIP, both far stronger than Andrew Abbott's approximately 159.0 innings with a 4.70 ERA and 4.98 FIP. Chase Burns is listed on the 15-Day IL for Cincinnati, while Bryce Elder is listed on the 15-Day IL for Atlanta.

Statistical scope: MLB Stats API; 2026 regular season season-to-date; exact statistical through-date not supplied.

WP selection: Braves -1.5. Confidence: Lock.

The selection is supplied separately by WP. The comparisons above do not establish why the model made this selection.

WP home-run candidate for Braves: Ronald Acuña Jr.. The selection uses roster and season-stat inputs; it does not establish a confirmed batting lineup or favourable betting odds.

WP home-run candidate for Reds: Elly De La Cruz. The selection uses roster and season-stat inputs; it does not establish a confirmed batting lineup or favourable betting odds.

Chicago White Sox at Kansas City Royals

Chicago's pitching staff holds the edge over Kansas City with a 4.34 FIP and 4.15 ERA against the Royals' 4.76 FIP and 4.72 ERA, while the offensive gap is narrower with the White Sox at 0.316 wOBA and the Royals at 0.310. The staff figures point toward Chicago as the stronger side on paper.

Bryan Hudson has posted a 3.03 ERA and 3.32 FIP across approximately 65.3 innings, both markedly better than Seth Lugo's approximately 169.0 innings with a 5.06 ERA and 4.47 FIP. Joey Bart is listed on the 10-Day IL for Chicago, while Luinder Avila and Ryan Bergert are both listed on the 60-Day IL for Kansas City.

Statistical scope: MLB Stats API; 2026 regular season season-to-date; exact statistical through-date not supplied.

WP selection: White Sox moneyline. Confidence: Confident.

The selection is supplied separately by WP. The comparisons above do not establish why the model made this selection.

WP home-run candidate for Royals: Jac Caglianone. The selection uses roster and season-stat inputs; it does not establish a confirmed batting lineup or favourable betting odds.

WP home-run candidate for White Sox: Randal Grichuk. The selection uses roster and season-stat inputs; it does not establish a confirmed batting lineup or favourable betting odds.

Miami Marlins at Chicago Cubs

Chicago's offense stands out in this one with a 0.334 wOBA that comfortably tops Miami's 0.317, though the Cubs' pitching staff trails with a 4.71 FIP against the Marlins' 4.24 FIP; the ERA figures are closer, with Chicago at 4.17 and Miami at 4.13. The mixed staff numbers make the offensive gap the most notable separator.

Kevin Gausman has worked approximately 172.0 innings with a 4.55 ERA but a better 3.82 FIP, while Ryan Gusto has logged approximately 82.7 innings with a 4.14 ERA and 4.36 FIP. Ben Brown and Brandon Birdsell are both listed on the 60-Day IL for Chicago, while Anthony Bender is listed on the 15-Day IL and Keyner Benitez on the 60-Day IL for Miami.

Statistical scope: MLB Stats API; 2026 regular season season-to-date; exact statistical through-date not supplied.

WP selection: Cubs moneyline. Confidence: Confident.

The selection is supplied separately by WP. The comparisons above do not establish why the model made this selection.

WP home-run candidate for Cubs: Michael Conforto. The selection uses roster and season-stat inputs; it does not establish a confirmed batting lineup or favourable betting odds.

WP home-run candidate for Marlins: Griffin Conine. The selection uses roster and season-stat inputs; it does not establish a confirmed batting lineup or favourable betting odds.

New York Mets at Texas Rangers

Texas and New York are closely matched offensively, with the Rangers' 0.311 wOBA just ahead of the Mets' 0.306, while the pitching staffs sit fairly close as well at 4.21 FIP and 4.28 ERA for Texas against 4.14 FIP and 4.15 ERA for New York. It is a tight statistical profile on both sides of the ball.

Nolan McLean has been effective over approximately 172.7 innings, posting a 3.18 ERA and 3.72 FIP for the Mets, while starting-pitcher information for the Rangers is unavailable in this preview. Boston Baro is listed on the 60-Day IL for New York, while Carter Baumler, Jalen Beeks and Paul Bonzagni are all listed on the 60-Day IL for Texas.

Statistical scope: MLB Stats API; 2026 regular season season-to-date; exact statistical through-date not supplied.

No rated WP selection is available in this article snapshot.

WP home-run candidate for Mets: Francisco Lindor. The selection uses roster and season-stat inputs; it does not establish a confirmed batting lineup or favourable betting odds.

WP home-run candidate for Rangers: Justin Foscue. The selection uses roster and season-stat inputs; it does not establish a confirmed batting lineup or favourable betting odds.

Arizona Diamondbacks at Colorado Rockies

Colorado's offense actually posts a higher wOBA at 0.319 compared to Arizona's 0.310, but the Rockies' pitching staff trails badly with a 4.91 FIP and 5.58 ERA against the Diamondbacks' 4.40 FIP and 4.09 ERA. That run-prevention gap gives Arizona the stronger overall profile in this one.

Merrill Kelly has posted a 5.00 ERA and 5.47 FIP across approximately 156.7 innings, while Mason Adams has an even higher 6.26 FIP paired with a 5.09 ERA over just approximately 23.0 innings for Colorado. Tyler Bell is listed as 'Out' for Colorado, while Brody Brecht and McCade Brown are both listed on the 60-Day IL for the Rockies, and Kyle Amendt is listed on the 60-Day IL for Arizona.

Statistical scope: MLB Stats API; 2026 regular season season-to-date; exact statistical through-date not supplied.

WP selection: Diamondbacks moneyline. Confidence: Confident.

The selection is supplied separately by WP. The comparisons above do not establish why the model made this selection.

WP home-run candidate for Diamondbacks: Corbin Carroll. The selection uses roster and season-stat inputs; it does not establish a confirmed batting lineup or favourable betting odds.

WP home-run candidate for Rockies: Mickey Moniak. The selection uses roster and season-stat inputs; it does not establish a confirmed batting lineup or favourable betting odds.

Los Angeles Angels at Oakland Athletics

Oakland's pitching staff is a significant weak spot in this matchup, carrying a 4.95 FIP and 5.45 ERA against the Angels' 4.15 FIP and 4.24 ERA, while the offensive comparison is closer with Oakland's 0.313 wOBA actually topping Los Angeles's 0.298. The staff gap gives the Angels the clearer statistical edge overall.

Walbert Ureña has been sharp across approximately 144.3 innings, posting a 2.74 ERA and 3.60 FIP, both well ahead of Jeffrey Springs's approximately 138.3 innings with a 6.18 ERA and 6.00 FIP. Jamie Arnold is listed as 'Out' for Oakland, while Nacho Alvarez and Rio Foster are both listed on the 60-Day IL for Los Angeles.

Statistical scope: MLB Stats API; 2026 regular season season-to-date; exact statistical through-date not supplied.

WP selection: Angels moneyline. Confidence: Confident.

The selection is supplied separately by WP. The comparisons above do not establish why the model made this selection.

WP home-run candidate for Angels: Mike Trout. The selection uses roster and season-stat inputs; it does not establish a confirmed batting lineup or favourable betting odds.

WP home-run candidate for Athletics: Brian Serven. The selection uses roster and season-stat inputs; it does not establish a confirmed batting lineup or favourable betting odds.

San Diego Padres at Los Angeles Dodgers

Los Angeles brings the stronger all-around profile into this one, with the Dodgers' 0.332 wOBA topping San Diego's 0.312, and their pitching staff also ahead with a 3.83 FIP and 3.59 ERA compared to the Padres' 4.26 FIP and 3.96 ERA. Both sides of the game favor the Dodgers on the listed figures.

Yoshinobu Yamamoto has been excellent over approximately 179.0 innings, with a 2.51 ERA and 3.35 FIP, both better than Robbie Ray's approximately 162.3 innings with a 3.60 ERA and 4.80 FIP. Jason Adam is listed on the 60-Day IL and Miguel Andujar on the 10-Day IL for San Diego, while Yency Almonte and Ben Casparius are both listed on the 60-Day IL for Los Angeles.

Statistical scope: MLB Stats API; 2026 regular season season-to-date; exact statistical through-date not supplied.

WP selection: Dodgers moneyline. Confidence: Strong.

The selection is supplied separately by WP. The comparisons above do not establish why the model made this selection.

WP home-run candidate for Dodgers: Mookie Betts. The selection uses roster and season-stat inputs; it does not establish a confirmed batting lineup or favourable betting odds.

WP home-run candidate for Padres: Ethan Salas. The selection uses roster and season-stat inputs; it does not establish a confirmed batting lineup or favourable betting odds.

Houston Astros at Seattle Mariners

Seattle's pitching staff has a modest edge over Houston with a 4.08 FIP against the Astros' 4.63 FIP, even though Houston's ERA at 4.50 sits close to Seattle's 4.21. Houston's offense holds a slightly higher 0.314 wOBA compared to the Mariners' 0.303, keeping the overall picture fairly balanced.

George Kirby has logged approximately 169.7 innings with a 4.24 ERA and a better 3.92 FIP, while Ethan Pecko has worked just approximately 28.7 innings with a 3.77 ERA but a higher 5.58 FIP. Matt Brash is listed on the 60-Day IL for Seattle, while Brandon Bielak, Jax Biggers and Drew Brutcher are all listed on the 60-Day IL for Houston.

Statistical scope: MLB Stats API; 2026 regular season season-to-date; exact statistical through-date not supplied.

WP selection: Astros +1.5. Confidence: Slight Lean.

The selection is supplied separately by WP. The comparisons above do not establish why the model made this selection.

WP home-run candidate for Astros: Nelson Velázquez. The selection uses roster and season-stat inputs; it does not establish a confirmed batting lineup or favourable betting odds.

WP home-run candidate for Mariners: Lazaro Montes. The selection uses roster and season-stat inputs; it does not establish a confirmed batting lineup or favourable betting odds.

Predictions are uncertain; no outcome is guaranteed. Check the picks page for the latest available selections.

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