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MLB Predictions for September 25, 2026: Every Game Previewed

2026-09-25 · Posted at 9:41 AM ET

Preview for Friday, September 25, 2026. Schedule and player information can change.

Pittsburgh Pirates at Detroit Tigers

This matchup has the Pittsburgh Pirates visiting the Detroit Tigers. The listed start is 6:40 PM ET.

Among the listed starters, Jackson Jobe has the lower ERA in these records. Bubba Chandler, the listed starter for the Pittsburgh Pirates, has an ERA of 4.34 and a WP-calculated FIP of 4.28 in the available pitching data, covering approximately 151.3 innings. Jackson Jobe, the listed starter for the Detroit Tigers, has an ERA of 3.98 and a WP-calculated FIP of 4.62 in the available pitching data, covering approximately 40.7 innings. These are schedule listings, not independent confirmation of the final starters.

The available team ERA figure is lower for the Detroit Tigers. Team statistics for the Pittsburgh Pirates show a WP-estimated wOBA of 0.321, a WP-estimated FIP of 3.88 and an ERA of 4.15. Team statistics for the Detroit Tigers show a WP-estimated wOBA of 0.313, a WP-estimated FIP of 4.09 and an ERA of 3.65.

Statistical scope: MLB Stats API; 2026 regular season to date; exact statistical through-date not supplied.

WP selection: Pirates +1.5. Confidence: Slight Lean.

This is the selection in the article’s data snapshot. The descriptive statistics above do not establish why the model made that selection.

WP home-run candidate for Pirates: Rafael Flores Jr.. The selection uses roster and season-stat inputs; it does not establish a confirmed batting lineup or favourable betting odds.

WP home-run candidate for Tigers: Eduardo Valencia. The selection uses roster and season-stat inputs; it does not establish a confirmed batting lineup or favourable betting odds.

Tampa Bay Rays at Philadelphia Phillies

This matchup has the Tampa Bay Rays visiting the Philadelphia Phillies. The listed start is 6:40 PM ET.

Among the listed starters, Cristopher Sánchez has the lower ERA in these records. Freddy Peralta, the listed starter for the Tampa Bay Rays, has an ERA of 4.56 and a WP-calculated FIP of 4.39 in the available pitching data, covering approximately 163.7 innings. Cristopher Sánchez, the listed starter for the Philadelphia Phillies, has an ERA of 2.93 and a WP-calculated FIP of 2.88 in the available pitching data, covering approximately 200.0 innings. These are schedule listings, not independent confirmation of the final starters.

The available team ERA figure is lower for the Tampa Bay Rays. Team statistics for the Tampa Bay Rays show a WP-estimated wOBA of 0.317, a WP-estimated FIP of 4.11 and an ERA of 3.73. Team statistics for the Philadelphia Phillies show a WP-estimated wOBA of 0.307, a WP-estimated FIP of 3.86 and an ERA of 4.01.

Statistical scope: MLB Stats API; 2026 regular season to date; exact statistical through-date not supplied.

WP selection: Rays +1.5. Confidence: Slight Lean.

This is the selection in the article’s data snapshot. The descriptive statistics above do not establish why the model made that selection.

WP home-run candidate for Phillies: Bryce Harper. The selection uses roster and season-stat inputs; it does not establish a confirmed batting lineup or favourable betting odds.

WP home-run candidate for Rays: Victor Mesa Jr.. The selection uses roster and season-stat inputs; it does not establish a confirmed batting lineup or favourable betting odds.

New York Mets at Washington Nationals

This matchup has the New York Mets visiting the Washington Nationals. The listed start is 6:45 PM ET.

The listed starter for the New York Mets is not available in this preview. Andrew Alvarez, the listed starter for the Washington Nationals, has an ERA of 3.17 and a WP-calculated FIP of 3.21 in the available pitching data, covering approximately 108.0 innings. These are schedule listings, not independent confirmation of the final starters.

The available team ERA figure is lower for the New York Mets. Team statistics for the New York Mets show a WP-estimated wOBA of 0.306, a WP-estimated FIP of 4.13 and an ERA of 4.14. Team statistics for the Washington Nationals show a WP-estimated wOBA of 0.322, a WP-estimated FIP of 4.77 and an ERA of 4.65.

Statistical scope: MLB Stats API; 2026 regular season to date; exact statistical through-date not supplied.

No rated WP selection is available in this article snapshot.

WP home-run candidate for Mets: Francisco Lindor. The selection uses roster and season-stat inputs; it does not establish a confirmed batting lineup or favourable betting odds.

WP home-run candidate for Nationals: Yohandy Morales. The selection uses roster and season-stat inputs; it does not establish a confirmed batting lineup or favourable betting odds.

Cincinnati Reds at Toronto Blue Jays

This matchup has the Cincinnati Reds visiting the Toronto Blue Jays. The listed start is 7:07 PM ET.

Nick Lodolo, the listed starter for the Cincinnati Reds, has an ERA of 5.04 and a WP-calculated FIP of 5.84 in the available pitching data, covering approximately 103.7 innings. The listed starter for the Toronto Blue Jays is not available in this preview. These are schedule listings, not independent confirmation of the final starters.

The available team ERA figure is lower for the Toronto Blue Jays. Team statistics for the Cincinnati Reds show a WP-estimated wOBA of 0.304, a WP-estimated FIP of 4.90 and an ERA of 4.85. Team statistics for the Toronto Blue Jays show a WP-estimated wOBA of 0.301, a WP-estimated FIP of 4.07 and an ERA of 3.92.

Statistical scope: MLB Stats API; 2026 regular season to date; exact statistical through-date not supplied.

No rated WP selection is available in this article snapshot.

WP home-run candidate for Blue Jays: Davis Schneider. The selection uses roster and season-stat inputs; it does not establish a confirmed batting lineup or favourable betting odds.

WP home-run candidate for Reds: Elly De La Cruz. The selection uses roster and season-stat inputs; it does not establish a confirmed batting lineup or favourable betting odds.

Atlanta Braves at Miami Marlins

This matchup has the Atlanta Braves visiting the Miami Marlins. The listed start is 7:10 PM ET.

The listed starter for the Atlanta Braves is not available in this preview. Eury Pérez, the listed starter for the Miami Marlins, has an ERA of 4.14 and a WP-calculated FIP of 4.28 in the available pitching data, covering approximately 150.0 innings. These are schedule listings, not independent confirmation of the final starters.

The available team ERA figure is lower for the Atlanta Braves. Team statistics for the Atlanta Braves show a WP-estimated wOBA of 0.312, a WP-estimated FIP of 4.17 and an ERA of 3.62. Team statistics for the Miami Marlins show a WP-estimated wOBA of 0.316, a WP-estimated FIP of 4.24 and an ERA of 4.10.

Statistical scope: MLB Stats API; 2026 regular season to date; exact statistical through-date not supplied.

No rated WP selection is available in this article snapshot.

WP home-run candidate for Braves: Ronald Acuña Jr.. The selection uses roster and season-stat inputs; it does not establish a confirmed batting lineup or favourable betting odds.

WP home-run candidate for Marlins: Griffin Conine. The selection uses roster and season-stat inputs; it does not establish a confirmed batting lineup or favourable betting odds.

Cleveland Guardians at Kansas City Royals

This matchup has the Cleveland Guardians visiting the Kansas City Royals. The listed start is 7:40 PM ET.

Among the listed starters, Gavin Williams has the lower ERA in these records. Gavin Williams, the listed starter for the Cleveland Guardians, has an ERA of 3.63 and a WP-calculated FIP of 3.46 in the available pitching data, covering approximately 181.0 innings. Noah Cameron, the listed starter for the Kansas City Royals, has an ERA of 3.92 and a WP-calculated FIP of 3.83 in the available pitching data, covering approximately 172.3 innings. These are schedule listings, not independent confirmation of the final starters.

The available team ERA figure is lower for the Cleveland Guardians. Team statistics for the Cleveland Guardians show a WP-estimated wOBA of 0.302, a WP-estimated FIP of 3.86 and an ERA of 3.73. Team statistics for the Kansas City Royals show a WP-estimated wOBA of 0.310, a WP-estimated FIP of 4.74 and an ERA of 4.73.

Statistical scope: MLB Stats API; 2026 regular season to date; exact statistical through-date not supplied.

WP selection: Guardians moneyline. Confidence: Confident.

This is the selection in the article’s data snapshot. The descriptive statistics above do not establish why the model made that selection.

WP home-run candidate for Guardians: Angel Martínez. The selection uses roster and season-stat inputs; it does not establish a confirmed batting lineup or favourable betting odds.

WP home-run candidate for Royals: Jac Caglianone. The selection uses roster and season-stat inputs; it does not establish a confirmed batting lineup or favourable betting odds.

Colorado Rockies at Chicago White Sox

This matchup has the Colorado Rockies visiting the Chicago White Sox. The listed start is 7:40 PM ET.

Among the listed starters, Sean Burke has the lower ERA in these records. Tomoyuki Sugano, the listed starter for the Colorado Rockies, has an ERA of 5.36 and a WP-calculated FIP of 5.46 in the available pitching data, covering approximately 147.7 innings. Sean Burke, the listed starter for the Chicago White Sox, has an ERA of 3.40 and a WP-calculated FIP of 3.70 in the available pitching data, covering approximately 167.0 innings. These are schedule listings, not independent confirmation of the final starters.

The available team ERA figure is lower for the Chicago White Sox. Team statistics for the Colorado Rockies show a WP-estimated wOBA of 0.320, a WP-estimated FIP of 4.91 and an ERA of 5.59. Team statistics for the Chicago White Sox show a WP-estimated wOBA of 0.316, a WP-estimated FIP of 4.32 and an ERA of 4.13.

Statistical scope: MLB Stats API; 2026 regular season to date; exact statistical through-date not supplied.

WP selection: White Sox moneyline. Confidence: Strong.

This is the selection in the article’s data snapshot. The descriptive statistics above do not establish why the model made that selection.

WP home-run candidate for Rockies: Mickey Moniak. The selection uses roster and season-stat inputs; it does not establish a confirmed batting lineup or favourable betting odds.

WP home-run candidate for White Sox: Randal Grichuk. The selection uses roster and season-stat inputs; it does not establish a confirmed batting lineup or favourable betting odds.

St. Louis Cardinals at Milwaukee Brewers

This matchup has the St. Louis Cardinals visiting the Milwaukee Brewers. The listed start is 7:40 PM ET.

Among the listed starters, Michael McGreevy has the lower ERA in these records. Michael McGreevy, the listed starter for the St. Louis Cardinals, has an ERA of 3.84 and a WP-calculated FIP of 4.32 in the available pitching data, covering approximately 164.0 innings. Robert Gasser, the listed starter for the Milwaukee Brewers, has an ERA of 4.01 and a WP-calculated FIP of 4.39 in the available pitching data, covering approximately 103.3 innings. These are schedule listings, not independent confirmation of the final starters.

The available team ERA figure is lower for the Milwaukee Brewers. Team statistics for the St. Louis Cardinals show a WP-estimated wOBA of 0.304, a WP-estimated FIP of 4.15 and an ERA of 4.24. Team statistics for the Milwaukee Brewers show a WP-estimated wOBA of 0.324, a WP-estimated FIP of 3.78 and an ERA of 3.52.

Statistical scope: MLB Stats API; 2026 regular season to date; exact statistical through-date not supplied.

WP selection: Brewers moneyline. Confidence: Confident.

This is the selection in the article’s data snapshot. The descriptive statistics above do not establish why the model made that selection.

WP home-run candidate for Brewers: Jackson Chourio. The selection uses roster and season-stat inputs; it does not establish a confirmed batting lineup or favourable betting odds.

WP home-run candidate for Cardinals: Leo Bernal. The selection uses roster and season-stat inputs; it does not establish a confirmed batting lineup or favourable betting odds.

Texas Rangers at Minnesota Twins

This matchup has the Texas Rangers visiting the Minnesota Twins. The listed start is 8:10 PM ET.

Among the listed starters, Joe Ryan has the lower ERA in these records. Jacob deGrom, the listed starter for the Texas Rangers, has an ERA of 3.86 and a WP-calculated FIP of 3.19 in the available pitching data, covering approximately 158.7 innings. Joe Ryan, the listed starter for the Minnesota Twins, has an ERA of 3.83 and a WP-calculated FIP of 3.83 in the available pitching data, covering approximately 138.7 innings. These are schedule listings, not independent confirmation of the final starters.

The available team ERA figure is lower for the Texas Rangers. Team statistics for the Texas Rangers show a WP-estimated wOBA of 0.310, a WP-estimated FIP of 4.22 and an ERA of 4.28. Team statistics for the Minnesota Twins show a WP-estimated wOBA of 0.312, a WP-estimated FIP of 4.29 and an ERA of 4.57.

Statistical scope: MLB Stats API; 2026 regular season to date; exact statistical through-date not supplied.

WP selection: Twins +1.5. Confidence: Slight Lean.

This is the selection in the article’s data snapshot. The descriptive statistics above do not establish why the model made that selection.

WP home-run candidate for Rangers: Justin Foscue. The selection uses roster and season-stat inputs; it does not establish a confirmed batting lineup or favourable betting odds.

WP home-run candidate for Twins: Emmanuel Rodriguez. The selection uses roster and season-stat inputs; it does not establish a confirmed batting lineup or favourable betting odds.

Houston Astros at Oakland Athletics

This matchup has the Houston Astros visiting the Oakland Athletics. The listed start is 9:40 PM ET.

Among the listed starters, Hunter Brown has the lower ERA in these records. Hunter Brown, the listed starter for the Houston Astros, has an ERA of 3.26 and a WP-calculated FIP of 3.84 in the available pitching data, covering approximately 102.0 innings. Jacob Lopez, the listed starter for the Oakland Athletics, has an ERA of 5.68 and a WP-calculated FIP of 5.30 in the available pitching data, covering approximately 117.3 innings. These are schedule listings, not independent confirmation of the final starters.

The available team ERA figure is lower for the Houston Astros. Team statistics for the Houston Astros show a WP-estimated wOBA of 0.315, a WP-estimated FIP of 4.63 and an ERA of 4.50. Team statistics for the Oakland Athletics show a WP-estimated wOBA of 0.315, a WP-estimated FIP of 4.98 and an ERA of 5.44.

Statistical scope: MLB Stats API; 2026 regular season to date; exact statistical through-date not supplied.

WP selection: Astros moneyline. Confidence: Confident.

This is the selection in the article’s data snapshot. The descriptive statistics above do not establish why the model made that selection.

WP home-run candidate for Astros: Nelson Velázquez. The selection uses roster and season-stat inputs; it does not establish a confirmed batting lineup or favourable betting odds.

WP home-run candidate for Athletics: Zack Gelof. The selection uses roster and season-stat inputs; it does not establish a confirmed batting lineup or favourable betting odds.

Arizona Diamondbacks at San Diego Padres

This matchup has the Arizona Diamondbacks visiting the San Diego Padres. The listed start is 9:40 PM ET.

Brandon Pfaadt, the listed starter for the Arizona Diamondbacks, has an ERA of 3.72 and a WP-calculated FIP of 4.07 in the available pitching data, covering approximately 128.3 innings. The listed starter for the San Diego Padres is not available in this preview. These are schedule listings, not independent confirmation of the final starters.

The available team ERA figure is lower for the San Diego Padres. Team statistics for the Arizona Diamondbacks show a WP-estimated wOBA of 0.312, a WP-estimated FIP of 4.41 and an ERA of 4.10. Team statistics for the San Diego Padres show a WP-estimated wOBA of 0.311, a WP-estimated FIP of 4.24 and an ERA of 3.93.

Statistical scope: MLB Stats API; 2026 regular season to date; exact statistical through-date not supplied.

No rated WP selection is available in this article snapshot.

WP home-run candidate for Diamondbacks: Corbin Carroll. The selection uses roster and season-stat inputs; it does not establish a confirmed batting lineup or favourable betting odds.

WP home-run candidate for Padres: Ty France. The selection uses roster and season-stat inputs; it does not establish a confirmed batting lineup or favourable betting odds.

Los Angeles Angels at Seattle Mariners

This matchup has the Los Angeles Angels visiting the Seattle Mariners. The listed start is 10:10 PM ET.

Among the listed starters, Reid Detmers has the lower ERA in these records. Reid Detmers, the listed starter for the Los Angeles Angels, has an ERA of 3.47 and a WP-calculated FIP of 3.13 in the available pitching data, covering approximately 179.0 innings. Bryce Miller, the listed starter for the Seattle Mariners, has an ERA of 3.99 and a WP-calculated FIP of 4.50 in the available pitching data, covering approximately 112.7 innings. These are schedule listings, not independent confirmation of the final starters.

The available team ERA figure is lower for the Seattle Mariners. Team statistics for the Los Angeles Angels show a WP-estimated wOBA of 0.299, a WP-estimated FIP of 4.16 and an ERA of 4.26. Team statistics for the Seattle Mariners show a WP-estimated wOBA of 0.303, a WP-estimated FIP of 4.07 and an ERA of 4.21.

Statistical scope: MLB Stats API; 2026 regular season to date; exact statistical through-date not supplied.

WP selection: Angels +1.5. Confidence: Slight Lean.

This is the selection in the article’s data snapshot. The descriptive statistics above do not establish why the model made that selection.

WP home-run candidate for Angels: Mike Trout. The selection uses roster and season-stat inputs; it does not establish a confirmed batting lineup or favourable betting odds.

WP home-run candidate for Mariners: Lazaro Montes. The selection uses roster and season-stat inputs; it does not establish a confirmed batting lineup or favourable betting odds.

Los Angeles Dodgers at San Francisco Giants

This matchup has the Los Angeles Dodgers visiting the San Francisco Giants. The listed start is 10:15 PM ET.

Among the listed starters, Tarik Skubal has the lower ERA in these records. Tarik Skubal, the listed starter for the Los Angeles Dodgers, has an ERA of 2.85 and a WP-calculated FIP of 2.68 in the available pitching data, covering approximately 151.7 innings. Yunior Marte, the listed starter for the San Francisco Giants, has an ERA of 4.66 and a WP-calculated FIP of 5.45 in the available pitching data, covering approximately 19.3 innings. These are schedule listings, not independent confirmation of the final starters.

The available team ERA figure is lower for the Los Angeles Dodgers. Team statistics for the Los Angeles Dodgers show a WP-estimated wOBA of 0.331, a WP-estimated FIP of 3.82 and an ERA of 3.59. Team statistics for the San Francisco Giants show a WP-estimated wOBA of 0.308, a WP-estimated FIP of 4.32 and an ERA of 4.36.

Statistical scope: MLB Stats API; 2026 regular season to date; exact statistical through-date not supplied.

WP selection: Dodgers -1.5. Confidence: Lock.

This is the selection in the article’s data snapshot. The descriptive statistics above do not establish why the model made that selection.

WP home-run candidate for Dodgers: Max Muncy. The selection uses roster and season-stat inputs; it does not establish a confirmed batting lineup or favourable betting odds.

WP home-run candidate for Giants: Victor Bericoto. The selection uses roster and season-stat inputs; it does not establish a confirmed batting lineup or favourable betting odds.

Predictions are uncertain; no outcome is guaranteed. Check the picks page for the latest available selections.

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