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MLB Predictions for September 22, 2026: Every Game Previewed

2026-09-22 · Posted at 9:41 AM ET

Preview for Tuesday, September 22, 2026. Schedule and player information can change.

Toronto Blue Jays at Baltimore Orioles

This matchup has the Toronto Blue Jays visiting the Baltimore Orioles. The listed start is 6:35 PM ET.

Among the listed starters, Chris Bassitt has the lower ERA in these records. Max Scherzer, the listed starter for the Toronto Blue Jays, has an ERA of 6.07 and a WP-calculated FIP of 5.55 in the available pitching data, covering approximately 72.7 innings. Chris Bassitt, the listed starter for the Baltimore Orioles, has an ERA of 4.64 and a WP-calculated FIP of 4.45 in the available pitching data, covering approximately 97.0 innings. These are schedule listings, not independent confirmation of the final starters.

The available team ERA figure is lower for the Toronto Blue Jays. Team statistics for the Toronto Blue Jays show a WP-estimated wOBA of 0.302, a WP-estimated FIP of 4.08 and an ERA of 3.92. Team statistics for the Baltimore Orioles show a WP-estimated wOBA of 0.309, a WP-estimated FIP of 4.15 and an ERA of 4.11.

Statistical scope: MLB Stats API; 2026 regular season to date; exact statistical through-date not supplied.

WP selection: Blue Jays +1.5. Confidence: Slight Lean.

This is the selection in the article’s data snapshot. The descriptive statistics above do not establish why the model made that selection.

WP home-run candidate for Blue Jays: Sean Keys. The selection uses roster and season-stat inputs; it does not establish a confirmed batting lineup or favourable betting odds.

WP home-run candidate for Orioles: Coby Mayo. The selection uses roster and season-stat inputs; it does not establish a confirmed batting lineup or favourable betting odds.

Washington Nationals at Detroit Tigers

This matchup has the Washington Nationals visiting the Detroit Tigers. The listed start is 6:40 PM ET.

Among the listed starters, Drew Anderson has the lower ERA in these records. Jackson Kent, the listed starter for the Washington Nationals, has an ERA of 6.40 and a WP-calculated FIP of 4.44 in the available pitching data, covering approximately 32.3 innings. Drew Anderson, the listed starter for the Detroit Tigers, has an ERA of 3.62 and a WP-calculated FIP of 4.26 in the available pitching data, covering approximately 102.0 innings. These are schedule listings, not independent confirmation of the final starters.

The available team ERA figure is lower for the Detroit Tigers. Team statistics for the Washington Nationals show a WP-estimated wOBA of 0.322, a WP-estimated FIP of 4.78 and an ERA of 4.69. Team statistics for the Detroit Tigers show a WP-estimated wOBA of 0.313, a WP-estimated FIP of 4.09 and an ERA of 3.65.

Statistical scope: MLB Stats API; 2026 regular season to date; exact statistical through-date not supplied.

WP selection: Tigers moneyline. Confidence: Confident.

This is the selection in the article’s data snapshot. The descriptive statistics above do not establish why the model made that selection.

WP home-run candidate for Nationals: Yohandy Morales. The selection uses roster and season-stat inputs; it does not establish a confirmed batting lineup or favourable betting odds.

WP home-run candidate for Tigers: Eduardo Valencia. The selection uses roster and season-stat inputs; it does not establish a confirmed batting lineup or favourable betting odds.

St. Louis Cardinals at Pittsburgh Pirates

This matchup has the St. Louis Cardinals visiting the Pittsburgh Pirates. The listed start is 6:40 PM ET.

Among the listed starters, Andre Pallante has the lower ERA in these records. Andre Pallante, the listed starter for the St. Louis Cardinals, has an ERA of 3.70 and a WP-calculated FIP of 3.79 in the available pitching data, covering approximately 151.0 innings. Jared Jones, the listed starter for the Pittsburgh Pirates, has an ERA of 4.17 and a WP-calculated FIP of 3.58 in the available pitching data, covering approximately 90.7 innings. These are schedule listings, not independent confirmation of the final starters.

The available team ERA figure is lower for the Pittsburgh Pirates. Team statistics for the St. Louis Cardinals show a WP-estimated wOBA of 0.305, a WP-estimated FIP of 4.17 and an ERA of 4.29. Team statistics for the Pittsburgh Pirates show a WP-estimated wOBA of 0.322, a WP-estimated FIP of 3.91 and an ERA of 4.19.

Statistical scope: MLB Stats API; 2026 regular season to date; exact statistical through-date not supplied.

WP selection: Pirates moneyline. Confidence: Confident.

This is the selection in the article’s data snapshot. The descriptive statistics above do not establish why the model made that selection.

WP home-run candidate for Cardinals: Leo Bernal. The selection uses roster and season-stat inputs; it does not establish a confirmed batting lineup or favourable betting odds.

WP home-run candidate for Pirates: Rafael Flores Jr.. The selection uses roster and season-stat inputs; it does not establish a confirmed batting lineup or favourable betting odds.

Milwaukee Brewers at Philadelphia Phillies

This matchup has the Milwaukee Brewers visiting the Philadelphia Phillies. The listed start is 6:40 PM ET.

Among the listed starters, Zack Wheeler has the lower ERA in these records. Dustin May, the listed starter for the Milwaukee Brewers, has an ERA of 4.61 and a WP-calculated FIP of 3.57 in the available pitching data, covering approximately 140.7 innings. Zack Wheeler, the listed starter for the Philadelphia Phillies, has an ERA of 2.99 and a WP-calculated FIP of 3.54 in the available pitching data, covering approximately 150.3 innings. These are schedule listings, not independent confirmation of the final starters.

The available team ERA figure is lower for the Milwaukee Brewers. Team statistics for the Milwaukee Brewers show a WP-estimated wOBA of 0.325, a WP-estimated FIP of 3.78 and an ERA of 3.54. Team statistics for the Philadelphia Phillies show a WP-estimated wOBA of 0.308, a WP-estimated FIP of 3.88 and an ERA of 4.00.

Statistical scope: MLB Stats API; 2026 regular season to date; exact statistical through-date not supplied.

WP selection: Brewers +1.5. Confidence: Slight Lean.

This is the selection in the article’s data snapshot. The descriptive statistics above do not establish why the model made that selection.

WP home-run candidate for Brewers: Gary Sánchez. The selection uses roster and season-stat inputs; it does not establish a confirmed batting lineup or favourable betting odds.

WP home-run candidate for Phillies: Bryce Harper. The selection uses roster and season-stat inputs; it does not establish a confirmed batting lineup or favourable betting odds.

Cleveland Guardians at Boston Red Sox

This matchup has the Cleveland Guardians visiting the Boston Red Sox. The listed start is 6:45 PM ET.

Among the listed starters, Parker Messick has the lower ERA in these records. Parker Messick, the listed starter for the Cleveland Guardians, has an ERA of 2.57 and a WP-calculated FIP of 3.18 in the available pitching data, covering approximately 178.3 innings. Payton Tolle, the listed starter for the Boston Red Sox, has an ERA of 3.02 and a WP-calculated FIP of 3.11 in the available pitching data, covering approximately 143.0 innings. These are schedule listings, not independent confirmation of the final starters.

The available team ERA figure is lower for the Boston Red Sox. Team statistics for the Cleveland Guardians show a WP-estimated wOBA of 0.303, a WP-estimated FIP of 3.89 and an ERA of 3.78. Team statistics for the Boston Red Sox show a WP-estimated wOBA of 0.314, a WP-estimated FIP of 3.74 and an ERA of 3.59.

Statistical scope: MLB Stats API; 2026 regular season to date; exact statistical through-date not supplied.

WP selection: Guardians +1.5. Confidence: Slight Lean.

This is the selection in the article’s data snapshot. The descriptive statistics above do not establish why the model made that selection.

WP home-run candidate for Guardians: Angel Martínez. The selection uses roster and season-stat inputs; it does not establish a confirmed batting lineup or favourable betting odds.

WP home-run candidate for Red Sox: Mickey Gasper. The selection uses roster and season-stat inputs; it does not establish a confirmed batting lineup or favourable betting odds.

Cincinnati Reds at Atlanta Braves

This matchup has the Cincinnati Reds visiting the Atlanta Braves. The listed start is 7:15 PM ET.

Among the listed starters, JR Ritchie has the lower ERA in these records. Brandon Williamson, the listed starter for the Cincinnati Reds, has an ERA of 5.56 and a WP-calculated FIP of 6.26 in the available pitching data, covering approximately 43.7 innings. JR Ritchie, the listed starter for the Atlanta Braves, has an ERA of 5.03 and a WP-calculated FIP of 5.71 in the available pitching data, covering approximately 62.7 innings. These are schedule listings, not independent confirmation of the final starters.

The available team ERA figure is lower for the Atlanta Braves. Team statistics for the Cincinnati Reds show a WP-estimated wOBA of 0.304, a WP-estimated FIP of 4.91 and an ERA of 4.89. Team statistics for the Atlanta Braves show a WP-estimated wOBA of 0.312, a WP-estimated FIP of 4.15 and an ERA of 3.61.

Statistical scope: MLB Stats API; 2026 regular season to date; exact statistical through-date not supplied.

WP selection: Braves moneyline. Confidence: Strong.

This is the selection in the article’s data snapshot. The descriptive statistics above do not establish why the model made that selection.

WP home-run candidate for Braves: Ronald Acuña Jr.. The selection uses roster and season-stat inputs; it does not establish a confirmed batting lineup or favourable betting odds.

WP home-run candidate for Reds: Elly De La Cruz. The selection uses roster and season-stat inputs; it does not establish a confirmed batting lineup or favourable betting odds.

Chicago White Sox at Kansas City Royals

This matchup has the Chicago White Sox visiting the Kansas City Royals. The listed start is 7:40 PM ET.

Among the listed starters, Daniel Lynch IV has the lower ERA in these records. Anthony Kay, the listed starter for the Chicago White Sox, has an ERA of 4.41 and a WP-calculated FIP of 4.84 in the available pitching data, covering approximately 149.0 innings. Daniel Lynch IV, the listed starter for the Kansas City Royals, has an ERA of 3.29 and a WP-calculated FIP of 3.85 in the available pitching data, covering approximately 76.7 innings. These are schedule listings, not independent confirmation of the final starters.

The available team ERA figure is lower for the Chicago White Sox. Team statistics for the Chicago White Sox show a WP-estimated wOBA of 0.314, a WP-estimated FIP of 4.33 and an ERA of 4.11. Team statistics for the Kansas City Royals show a WP-estimated wOBA of 0.310, a WP-estimated FIP of 4.73 and an ERA of 4.66.

Statistical scope: MLB Stats API; 2026 regular season to date; exact statistical through-date not supplied.

WP selection: Royals +1.5. Confidence: Slight Lean.

This is the selection in the article’s data snapshot. The descriptive statistics above do not establish why the model made that selection.

WP home-run candidate for Royals: Jac Caglianone. The selection uses roster and season-stat inputs; it does not establish a confirmed batting lineup or favourable betting odds.

WP home-run candidate for White Sox: Munetaka Murakami. The selection uses roster and season-stat inputs; it does not establish a confirmed batting lineup or favourable betting odds.

Miami Marlins at Chicago Cubs

This matchup has the Miami Marlins visiting the Chicago Cubs. The listed start is 7:40 PM ET.

Janson Junk, the listed starter for the Miami Marlins, has an ERA of 4.50 and a WP-calculated FIP of 4.32 in the available pitching data, covering approximately 114.0 innings. The listed starter for the Chicago Cubs is not available in this preview. These are schedule listings, not independent confirmation of the final starters.

Team statistics for the Miami Marlins show a WP-estimated wOBA of 0.317, a WP-estimated FIP of 4.26 and an ERA of 4.16. Team statistics for the Chicago Cubs show a WP-estimated wOBA of 0.335, a WP-estimated FIP of 4.72 and an ERA of 4.16.

Statistical scope: MLB Stats API; 2026 regular season to date; exact statistical through-date not supplied.

No rated WP selection is available in this article snapshot.

WP home-run candidate for Cubs: Michael Conforto. The selection uses roster and season-stat inputs; it does not establish a confirmed batting lineup or favourable betting odds.

WP home-run candidate for Marlins: Griffin Conine. The selection uses roster and season-stat inputs; it does not establish a confirmed batting lineup or favourable betting odds.

New York Mets at Texas Rangers

This matchup has the New York Mets visiting the Texas Rangers. The listed start is 8:05 PM ET.

Among the listed starters, MacKenzie Gore has the lower ERA in these records. Sean Manaea, the listed starter for the New York Mets, has an ERA of 4.74 and a WP-calculated FIP of 4.61 in the available pitching data, covering approximately 138.7 innings. MacKenzie Gore, the listed starter for the Texas Rangers, has an ERA of 4.67 and a WP-calculated FIP of 3.96 in the available pitching data, covering approximately 165.7 innings. These are schedule listings, not independent confirmation of the final starters.

The available team ERA figure is lower for the New York Mets. Team statistics for the New York Mets show a WP-estimated wOBA of 0.306, a WP-estimated FIP of 4.15 and an ERA of 4.17. Team statistics for the Texas Rangers show a WP-estimated wOBA of 0.312, a WP-estimated FIP of 4.21 and an ERA of 4.28.

Statistical scope: MLB Stats API; 2026 regular season to date; exact statistical through-date not supplied.

WP selection: Mets +1.5. Confidence: Slight Lean.

This is the selection in the article’s data snapshot. The descriptive statistics above do not establish why the model made that selection.

WP home-run candidate for Mets: Francisco Lindor. The selection uses roster and season-stat inputs; it does not establish a confirmed batting lineup or favourable betting odds.

WP home-run candidate for Rangers: Joc Pederson. The selection uses roster and season-stat inputs; it does not establish a confirmed batting lineup or favourable betting odds.

Arizona Diamondbacks at Colorado Rockies

This matchup has the Arizona Diamondbacks visiting the Colorado Rockies. The listed start is 8:40 PM ET.

Among the listed starters, Michael Soroka has the lower ERA in these records. Michael Soroka, the listed starter for the Arizona Diamondbacks, has an ERA of 3.45 and a WP-calculated FIP of 3.15 in the available pitching data, covering approximately 104.3 innings. Kyle Freeland, the listed starter for the Colorado Rockies, has an ERA of 6.38 and a WP-calculated FIP of 5.08 in the available pitching data, covering approximately 128.3 innings. These are schedule listings, not independent confirmation of the final starters.

The available team ERA figure is lower for the Arizona Diamondbacks. Team statistics for the Arizona Diamondbacks show a WP-estimated wOBA of 0.310, a WP-estimated FIP of 4.40 and an ERA of 4.11. Team statistics for the Colorado Rockies show a WP-estimated wOBA of 0.320, a WP-estimated FIP of 4.91 and an ERA of 5.57.

Statistical scope: MLB Stats API; 2026 regular season to date; exact statistical through-date not supplied.

WP selection: Diamondbacks moneyline. Confidence: Confident.

This is the selection in the article’s data snapshot. The descriptive statistics above do not establish why the model made that selection.

WP home-run candidate for Diamondbacks: Corbin Carroll. The selection uses roster and season-stat inputs; it does not establish a confirmed batting lineup or favourable betting odds.

WP home-run candidate for Rockies: Adael Amador. The selection uses roster and season-stat inputs; it does not establish a confirmed batting lineup or favourable betting odds.

Los Angeles Angels at Oakland Athletics

This matchup has the Los Angeles Angels visiting the Oakland Athletics. The listed start is 9:40 PM ET.

Among the listed starters, Brady Basso has the lower ERA in these records. Yusei Kikuchi, the listed starter for the Los Angeles Angels, has an ERA of 5.02 and a WP-calculated FIP of 4.30 in the available pitching data, covering approximately 57.3 innings. Brady Basso, the listed starter for the Oakland Athletics, has an ERA of 4.50 and a WP-calculated FIP of 3.27 in the available pitching data, covering approximately 40.0 innings. These are schedule listings, not independent confirmation of the final starters.

The available team ERA figure is lower for the Los Angeles Angels. Team statistics for the Los Angeles Angels show a WP-estimated wOBA of 0.297, a WP-estimated FIP of 4.13 and an ERA of 4.21. Team statistics for the Oakland Athletics show a WP-estimated wOBA of 0.312, a WP-estimated FIP of 4.95 and an ERA of 5.44.

Statistical scope: MLB Stats API; 2026 regular season to date; exact statistical through-date not supplied.

WP selection: Athletics +1.5. Confidence: Slight Lean.

This is the selection in the article’s data snapshot. The descriptive statistics above do not establish why the model made that selection.

WP home-run candidate for Angels: Mike Trout. The selection uses roster and season-stat inputs; it does not establish a confirmed batting lineup or favourable betting odds.

WP home-run candidate for Athletics: Brian Serven. The selection uses roster and season-stat inputs; it does not establish a confirmed batting lineup or favourable betting odds.

Houston Astros at Seattle Mariners

This matchup has the Houston Astros visiting the Seattle Mariners. The listed start is 9:40 PM ET.

Among the listed starters, Logan Gilbert has the lower ERA in these records. Cristian Javier, the listed starter for the Houston Astros, has an ERA of 5.31 and a WP-calculated FIP of 4.81 in the available pitching data, covering approximately 61.0 innings. Logan Gilbert, the listed starter for the Seattle Mariners, has an ERA of 3.69 and a WP-calculated FIP of 3.93 in the available pitching data, covering approximately 178.0 innings. These are schedule listings, not independent confirmation of the final starters.

The available team ERA figure is lower for the Seattle Mariners. Team statistics for the Houston Astros show a WP-estimated wOBA of 0.313, a WP-estimated FIP of 4.64 and an ERA of 4.53. Team statistics for the Seattle Mariners show a WP-estimated wOBA of 0.303, a WP-estimated FIP of 4.06 and an ERA of 4.19.

Statistical scope: MLB Stats API; 2026 regular season to date; exact statistical through-date not supplied.

WP selection: Astros +1.5. Confidence: Slight Lean.

This is the selection in the article’s data snapshot. The descriptive statistics above do not establish why the model made that selection.

WP home-run candidate for Astros: Nelson Velázquez. The selection uses roster and season-stat inputs; it does not establish a confirmed batting lineup or favourable betting odds.

WP home-run candidate for Mariners: Lazaro Montes. The selection uses roster and season-stat inputs; it does not establish a confirmed batting lineup or favourable betting odds.

Minnesota Twins at San Francisco Giants

This matchup has the Minnesota Twins visiting the San Francisco Giants. The listed start is 9:45 PM ET.

Among the listed starters, Taj Bradley has the lower ERA in these records. Taj Bradley, the listed starter for the Minnesota Twins, has an ERA of 3.81 and a WP-calculated FIP of 3.94 in the available pitching data, covering approximately 172.3 innings. Anthony Molina, the listed starter for the San Francisco Giants, has an ERA of 4.18 and a WP-calculated FIP of 3.42 in the available pitching data, covering approximately 28.0 innings. These are schedule listings, not independent confirmation of the final starters.

The available team ERA figure is lower for the San Francisco Giants. Team statistics for the Minnesota Twins show a WP-estimated wOBA of 0.312, a WP-estimated FIP of 4.31 and an ERA of 4.60. Team statistics for the San Francisco Giants show a WP-estimated wOBA of 0.309, a WP-estimated FIP of 4.32 and an ERA of 4.37.

Statistical scope: MLB Stats API; 2026 regular season to date; exact statistical through-date not supplied.

WP selection: Giants +1.5. Confidence: Slight Lean.

This is the selection in the article’s data snapshot. The descriptive statistics above do not establish why the model made that selection.

WP home-run candidate for Giants: Victor Bericoto. The selection uses roster and season-stat inputs; it does not establish a confirmed batting lineup or favourable betting odds.

WP home-run candidate for Twins: Emmanuel Rodriguez. The selection uses roster and season-stat inputs; it does not establish a confirmed batting lineup or favourable betting odds.

San Diego Padres at Los Angeles Dodgers

This matchup has the San Diego Padres visiting the Los Angeles Dodgers. The listed start is 10:10 PM ET.

Michael King, the listed starter for the San Diego Padres, has an ERA of 3.03 and a WP-calculated FIP of 4.23 in the available pitching data, covering approximately 181.0 innings. The listed starter for the Los Angeles Dodgers is not available in this preview. These are schedule listings, not independent confirmation of the final starters.

The available team ERA figure is lower for the Los Angeles Dodgers. Team statistics for the San Diego Padres show a WP-estimated wOBA of 0.313, a WP-estimated FIP of 4.25 and an ERA of 3.94. Team statistics for the Los Angeles Dodgers show a WP-estimated wOBA of 0.332, a WP-estimated FIP of 3.85 and an ERA of 3.62.

Statistical scope: MLB Stats API; 2026 regular season to date; exact statistical through-date not supplied.

No rated WP selection is available in this article snapshot.

WP home-run candidate for Dodgers: Mookie Betts. The selection uses roster and season-stat inputs; it does not establish a confirmed batting lineup or favourable betting odds.

WP home-run candidate for Padres: Ethan Salas. The selection uses roster and season-stat inputs; it does not establish a confirmed batting lineup or favourable betting odds.

Predictions are uncertain; no outcome is guaranteed. Check the picks page for the latest available selections.

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