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Diamondbacks vs. Padres Prediction — September 25, 2026

2026-09-25 · Posted at 9:43 AM ET · Diamondbacks @ Padres

Preview for Friday, September 25, 2026. Schedule and player information can change.

Arizona Diamondbacks at San Diego Padres

Arizona and San Diego arrive with strikingly similar offensive profiles, as the Diamondbacks carry a WP-estimated wOBA of 0.312 against the Padres' 0.311, essentially even production at the plate. On the run-prevention side the Padres hold a modest team-level edge, with a 4.24 FIP and 3.93 ERA compared to Arizona's 4.41 FIP and 4.10 ERA, suggesting San Diego's pitching staff as a whole has been the slightly stingier group this season.

Brandon Pfaadt takes the mound for Arizona and has been sharper than his team's broader numbers, posting a 3.72 ERA and a 4.07 FIP across roughly 128.3 innings pitched this season. That gives Pfaadt an individual profile that outperforms the Diamondbacks' team ERA and FIP figures. San Diego's starting pitcher information is unavailable in this preview, which limits a direct pitcher-versus-pitcher comparison for this matchup.

Several injury statuses are on record for both sides. Rotowire lists Kyle Amendt and Ryan Bruno of the Diamondbacks on the 60-Day IL, and Yordin Chalas on the 7-Day IL, while Miguel Andujar of the Padres is listed on the 10-Day IL and both Humberto Cruz and Yu Darvish of the Padres are listed as Out. With the offensive figures close to even and San Diego's team ERA and FIP both lower than Arizona's, the Padres' pitching numbers as a group provide a slight statistical edge in this contest, though Pfaadt's individual marks give Arizona a competitive counterpoint on the mound.

Statistical scope: MLB Stats API; 2026 regular season season-to-date; exact statistical through-date not supplied.

No rated WP selection is available in this article snapshot.

WP home-run candidate for Diamondbacks: Corbin Carroll. The selection uses roster and season-stat inputs; it does not establish a confirmed batting lineup or favourable betting odds.

WP home-run candidate for Padres: Ty France. The selection uses roster and season-stat inputs; it does not establish a confirmed batting lineup or favourable betting odds.

Predictions are uncertain; no outcome is guaranteed. Check the picks page for the latest available selections.

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