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Cardinals vs. Brewers Prediction — September 27, 2026

2026-09-27 · Posted at 9:43 AM ET · Cardinals @ Brewers

Preview for Sunday, September 27, 2026. Schedule and player information can change.

St. Louis Cardinals at Milwaukee Brewers

The Brewers hold the clearer edge on paper heading into this matchup, with a team wOBA of 0.325 that outpaces the Cardinals' 0.303, while Milwaukee's pitching staff also carries the better run-prevention marks with a 3.51 ERA and 3.78 FIP against St. Louis's 4.25 ERA and 4.15 FIP. That gap across both sides of the ball suggests Milwaukee is the stronger team by the numbers available here.

On the mound, Jacob Misiorowski has been excellent for Milwaukee this season, posting a 1.86 ERA and 2.23 FIP across approximately 169.3 innings pitched. Andre Pallante has also pitched well for St. Louis, with a 3.61 ERA and 3.78 FIP over roughly 157.0 innings, but his numbers still trail Misiorowski's by a clear margin, reinforcing Milwaukee's advantage in this pitching matchup.

Both rosters carry some injury-list activity. Grant Anderson and J.B. Bukauskas are listed on the 15-Day IL and 60-Day IL respectively for Milwaukee, while Sean Episcope is listed on the 60-Day IL for the Brewers as well. For St. Louis, Joshua Baez is listed on the 10-Day IL, Hunter Dobbins is listed on the 15-Day IL, and Frank Elissalt is listed on the 60-Day IL. None of these change the core numbers, which favor Milwaukee on both the offensive and pitching fronts.

Statistical scope: MLB Stats API; 2026 regular season season-to-date; exact statistical through-date not supplied.

WP selection: Brewers -1.5. Confidence: Lock.

The selection is supplied separately by WP. The comparisons above do not establish why the model made this selection.

WP home-run candidate for Brewers: Jackson Chourio. The selection uses roster and season-stat inputs; it does not establish a confirmed batting lineup or favourable betting odds.

WP home-run candidate for Cardinals: Alec Burleson. The selection uses roster and season-stat inputs; it does not establish a confirmed batting lineup or favourable betting odds.

Predictions are uncertain; no outcome is guaranteed. Check the picks page for the latest available selections.

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